Potent vasoconstriction mediated by endothelin ETB receptors in canine coronary arteries.

  title={Potent vasoconstriction mediated by endothelin ETB receptors in canine coronary arteries.},
  author={John R. Teerlink and Volker Breu and U Sprecher and Martine Clozel and J P Clozel},
  journal={Circulation research},
  volume={74 1},
Endothelin (ET) 1 is a powerful vasoconstrictor of coronary arteries and may play a role in coronary spasm, atherosclerosis, and myocardial infarction. Previous studies have demonstrated that intracoronary ET caused marked vasoconstriction of the coronary circulation; however, it remains unclear which ET receptor types are present and which of these receptors mediate this vasoconstriction. To characterize the ET receptors present in dog coronary arteries, competition binding assays with… CONTINUE READING


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