Potent topoisomerase I inhibition by novel silatecans eliminates glioma proliferation in vitro and in vivo.

@article{Pollack1999PotentTI,
  title={Potent topoisomerase I inhibition by novel silatecans eliminates glioma proliferation in vitro and in vivo.},
  author={Ian F Pollack and Melanie L Erff and David C Bom and Thomas G. Burke and J T Strode and Dennis P Curran},
  journal={Cancer research},
  year={1999},
  volume={59 19},
  pages={4898-905}
}
Although topoisomerase inhibitors, such as camptothecin and topotecan, have been widely used in the treatment of nonglial tumors, their application for gliomas has been limited by poor efficacy relative to toxicity that may in part reflect limited bioavailability and blood stability of these agents. However, the potential promise of this class of agents has fostered efforts to develop new, more potent, and less toxic inhibitors that may be clinically relevant. Using a cascade radical annulation… CONTINUE READING

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