Potent systemic antitumor activity from an oncolytic herpes simplex virus of syncytial phenotype.

@article{Fu2002PotentSA,
  title={Potent systemic antitumor activity from an oncolytic herpes simplex virus of syncytial phenotype.},
  author={Xinping Fu and Xiaoliu Zhang},
  journal={Cancer research},
  year={2002},
  volume={62 8},
  pages={2306-12}
}
Conditionally replicating (oncolytic) viruses, which selectively replicate in tumor cells but not in normal cells, show great promise as antitumor agents for cancer therapy. The principal antitumor activity of these viruses derives from their replication within tumor cells, which results in cell destruction and the production of progeny virions that can spread to adjacent tumor cells. However, one potential limitation of this approach is that viral gene deletions conferring tumor selectivity… CONTINUE READING

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An oncolytic herpes simplex virus type 1 selectively destroys diffuse liver metastases from colon carcinoma.

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