Potent synergic effect between ibuprofen and azoles on Candida resulting from blockade of efflux pumps as determined by FUN-1 staining and flow cytometry.

@article{PinaVaz2005PotentSE,
  title={Potent synergic effect between ibuprofen and azoles on Candida resulting from blockade of efflux pumps as determined by FUN-1 staining and flow cytometry.},
  author={Cid{\'a}lia Pina-Vaz and Ac{\'a}cio Agostinho Gonçalves Rodrigues and Sofia Costa-de-Oliveira and E. T. A. Ricardo and P -A M{\aa}rdh},
  journal={The Journal of antimicrobial chemotherapy},
  year={2005},
  volume={56 4},
  pages={678-85}
}
OBJECTIVES Resistance to antifungals often relates to efflux pumps exporting drugs; several modulators may block them, reverting resistance. Verapamil, beta-oestradiol and progesterone, known efflux pump inhibitors of human neoplastic cells, and ibuprofen were tested as potential modulators of resistance of Candida spp. METHODS Forty-two clinical isolates… CONTINUE READING