Potent stimulation of large‐conductance Ca2+‐activated K+ channels by rottlerin, an inhibitor of protein kinase C‐δ, in pituitary tumor (GH3) cells and in cortical neuronal (HCN‐1A) cells

@article{Wu2007PotentSO,
  title={Potent stimulation of large‐conductance Ca2+‐activated K+ channels by rottlerin, an inhibitor of protein kinase C‐$\delta$, in pituitary tumor (GH3) cells and in cortical neuronal (HCN‐1A) cells},
  author={Sheng-Nan Wu and Ya-Jean Wang and Ming-wei Lin},
  journal={Journal of Cellular Physiology},
  year={2007},
  volume={210}
}
The effects of rottlerin, a known inhibitor of protein kinase C‐δ activation, on ion currents were investigated in pituitary tumor (GH3) cells. Rottlerin (0.3–100 µM) increased the amplitude of Ca2+‐activated K+ current (IK(Ca)) in a concentration‐dependent manner with an EC50 value of 1.7 µM. In intracellular perfusion with rottlerin (1 µM) or staurosporine (10 µM), phorbol 12‐myristate 13‐acetate‐induced inhibition of IK(Ca) in these cells was abolished. In cell‐attached mode, rottlerin… Expand
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