Potent, selective MCH-1 receptor antagonists.


This paper describes the lead optimization of a new series of potent, selective, orally bioavailable, brain-penetrant MCH-1 receptor antagonists. A major focus of the work was to achieve a selectivity profile appropriate for in vivo efficacy studies and safety.

DOI: 10.1016/j.bmcl.2008.01.010

Cite this paper

@article{Erickson2008PotentSM, title={Potent, selective MCH-1 receptor antagonists.}, author={Shawn D Erickson and Bruce Banner and Steven J. Berthel and Karin Conde-Knape and Fiorenza Falcioni and Irina Hakimi and Bernard M. Hennessy and Robert F Kester and Kyungjin Kim and Chun Wai Manson Ma and Warren McComas and Francis A Mennona and Steven G Mischke and Lucy Orzechowski and Yimin Qian and Hamid Salari and John Tengi and Kshitij C Thakkar and Rebecca L Taub and Jefferson W Tilley and Hong Wang}, journal={Bioorganic & medicinal chemistry letters}, year={2008}, volume={18 4}, pages={1402-6} }