Potent plasmodicidal activity of a heat-induced reformulation of deoxycholate-amphotericin B (Fungizone) against Plasmodium falciparum.

@article{Hatabu2005PotentPA,
  title={Potent plasmodicidal activity of a heat-induced reformulation of deoxycholate-amphotericin B (Fungizone) against Plasmodium falciparum.},
  author={Toshimitsu Hatabu and Tsuyoshi Takada and Nao Taguchi and Mamoru Suzuki and Kumiko Sato and Shigeyuki Kano},
  journal={Antimicrobial agents and chemotherapy},
  year={2005},
  volume={49 2},
  pages={493-6}
}
The emergence and spread of drug-resistant Plasmodium falciparum continue to pose problems in malaria chemotherapy. Therefore, it is necessary to identify new antimalarial drugs and therapeutic strategies. In the present study, the activity of a heat-treated form of amphotericin B (HT-AMB) against P. falciparum was evaluated. The efficacy and toxicity of HT-AMB were also compared with those of the standard formulation (AMB). HT-AMB showed significant activity against a chloroquine-resistant… CONTINUE READING