Potent phagocytic activity with impaired antigen presentation identifying lipopolysaccharide-tolerant human monocytes: demonstration in isolated monocytes from cystic fibrosis patients.

@article{Fresno2009PotentPA,
  title={Potent phagocytic activity with impaired antigen presentation identifying lipopolysaccharide-tolerant human monocytes: demonstration in isolated monocytes from cystic fibrosis patients.},
  author={Carlos del Fresno and Francisco Garc{\'i}a-R{\'i}o and Vanesa G{\'o}mez-Pi{\~n}a and Alessandra Soares-Schanoski and Irene Fern{\'a}ndez-Ru{\'i}z and Teresa Jurado and Tasneem Shabbir Kajiji and Chen Shu and Elvira Mar{\'i}n and Ana Gutierrez del Arroyo and Concepci{\'o}n Prados and Francisco F Arnalich and Pablo Fuentes-Prior and Subhra Kumar Biswas and Eduardo L{\'o}pez-Collazo},
  journal={Journal of immunology},
  year={2009},
  volume={182 10},
  pages={6494-507}
}
Monocyte exposure to LPS induces a transient state in which these cells are refractory to further endotoxin stimulation. This phenomenon, termed endotoxin tolerance (ET), is characterized by a decreased production of cytokines in response to the proinflammatory stimulus. We have established a robust model of ET and have determined the time frame and features of LPS unresponsiveness in cultured human monocytes. A large number of genes transcribed in tolerant monocytes were classified as either… CONTINUE READING

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