Potent peptide inhibitors of human hepatitis C virus NS3 protease are obtained by optimizing the cleavage products.

@article{Ingallinella1998PotentPI,
  title={Potent peptide inhibitors of human hepatitis C virus NS3 protease are obtained by optimizing the cleavage products.},
  author={Paolo Ingallinella and Sergio Altamura and Elisabetta Bianchi and Marina Taliani and Raffaele Ingenito and R. Cortese and Raffaele De Francesco and Christian Steink{\"u}hler and Antonello Pessi},
  journal={Biochemistry},
  year={1998},
  volume={37 25},
  pages={8906-14}
}
In the absence of a broadly effective cure for hepatitis caused by hepatitis C virus (HCV), much effort is currently devoted to the search for inhibitors of the virally encoded protease NS3. This chymotrypsin-like serine protease is required for the maturation of the viral polyprotein, cleaving it at the NS3-NS4A, NS4A-NS4B, NS4B-NS5A, and NS5A-NS5B sites. In the course of our studies on the substrate specificity of NS3, we found that the products of cleavage corresponding to the P6-P1 region… CONTINUE READING

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