Potent oxazoline analog of apratoxin C: Synthesis, biological evaluation, and conformational analysis

@article{Yoshida2016PotentOA,
  title={Potent oxazoline analog of apratoxin C: Synthesis, biological evaluation, and conformational analysis},
  author={M. Yoshida and Y. Onda and Y. Masuda and T. Doi},
  journal={Peptide Science},
  year={2016},
  volume={106}
}
  • M. Yoshida, Y. Onda, +1 author T. Doi
  • Published 2016
  • Chemistry, Medicine
  • Peptide Science
    • In this research, the synthesis, biological evaluation, and conformational analysis of an apratoxin C oxazoline analog (3) have been demonstrated. The preparation of synthetic key intermediate 9 was achieved using an improved strategy that involves commercially available 3‐methylglutaric anhydride (12), an enzymatic enantioselective alcoholysis, and a diastereoselective reduction. The Pro‐Dtrina (3,7‐dihydroxy‐2,5,8‐trimethylnonanoic acid) moiety 8 was successfully synthesized in a similar… CONTINUE READING
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