Potent neutralization of vaccinia virus by divergent murine antibodies targeting a common site of vulnerability in L1 protein.

@article{Kaever2014PotentNO,
  title={Potent neutralization of vaccinia virus by divergent murine antibodies targeting a common site of vulnerability in L1 protein.},
  author={Thomas Kaever and Xiangzhi Meng and Michael H. Matho and Andrew M. Schlossman and Sheng Li and Inbal Sela-Culang and Yanay Ofran and Mark L. Buller and Ryan W. Crump and Scott Parker and April Frazier and Shane Crotty and Dirk M. Zajonc and Bjoern Peters and Yan Xiang},
  journal={Journal of virology},
  year={2014},
  volume={88 19},
  pages={11339-55}
}
UNLABELLED Vaccinia virus (VACV) L1 is an important target for viral neutralization and has been included in multicomponent DNA or protein vaccines against orthopoxviruses. To further understand the protective mechanism of the anti-L1 antibodies, we generated five murine anti-L1 monoclonal antibodies (MAbs), which clustered into 3 distinct epitope groups. While two groups of anti-L1 failed to neutralize, one group of 3 MAbs potently neutralized VACV in an isotype- and complement-independent… CONTINUE READING
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