Potent modulation of neuronal nicotinic acetylcholine receptor-channel by ethanol

@article{Nagata1996PotentMO,
  title={Potent modulation of neuronal nicotinic acetylcholine receptor-channel by ethanol},
  author={Keiichi Nagata and Gary L. Aistrup and Chao-Sheng Huang and William Marszalec and Toshio Narahashi},
  journal={Neuroscience Letters},
  year={1996},
  volume={217},
  pages={189-193}
}
Controversies remain over which ion channels are the most sensitive to ethanol. We have found that ethanol potently modulates the neuronal nicotinic acetylcholine receptor-channel at micromolar concentrations with an EC50 of 88.5 microM, which is significantly lower than most values previously reported for other ion channels. Prolonged application of ethanol accelerated the decay phase of acetylcholine-induced currents, caused single-channels to open in bursts, and shortened the mean open time… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 23 CITATIONS

Acute alcohol action and desensitization of ligand-gated ion channels.

  • Pharmacological reviews
  • 2009
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Modulation of the neuronal nicotinic acetylcholine receptor-channel by the nitromethylene heterocycle imidacloprid.

  • The Journal of pharmacology and experimental therapeutics
  • 1998
VIEW 6 EXCERPTS
CITES BACKGROUND, METHODS & RESULTS