Potent modulation of P‐glycoprotein activity by naturally occurring phenylbutenoids from Zingiber cassumunar

@article{Chung2009PotentMO,
  title={Potent modulation of P‐glycoprotein activity by naturally occurring phenylbutenoids from Zingiber cassumunar},
  author={S. Chung and A. Han and M. K. Sung and Ho-jin Jung and J. Nam and E. Seo and H. Lee},
  journal={Phytotherapy Research},
  year={2009},
  volume={23}
}
Five phenylbutenoid derivatives from the rhizomes of Zingiber cassumunar Roxb. (Zingiberaceae) were evaluated for their P‐glycoprotein (P‐gp) inhibitory effects in a P‐gp over‐expressing multidrug resistant (MDR) human breast cancer cell line, MCF‐7/ADR. As a result, a phenylbutenoid dimer, (±)‐trans‐3‐(3,4‐dimethoxyphenyl)‐4‐[(E)‐3,4‐dimethoxystyryl]cyclohex‐1‐ene (1), exhibited highly potent P‐gp inhibitory activity, decreasing the IC50 value of daunomycin (DNM) to 4.31 ± 0.40 µm in the cells… Expand
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