Potent modification of inducible CYP1A1 expression by flavonoids.

  title={Potent modification of inducible CYP1A1 expression by flavonoids.},
  author={Waranya Chatuphonprasert and Sachiko Kondo and Kanokwan Jarukamjorn and Yuki Kawasaki and Tsutomu Sakuma and Nobuo Nemoto},
  journal={Biological & pharmaceutical bulletin},
  volume={33 10},
The present study examined modifications of β-naphthoflavone (β-NF)-induced cytochrome P450 1A1 (CYP1A1) expression by flavonoids in mouse hepatocytes in primary culture. Some flavonoids (apigenin, chrysin, flavone, flavanone, galangin, luteolin, and naringenin) by themselves induced CYP1A1 mRNA expression, especially flavone which was even more effective than β-NF. The effect on β-NF-induced CYP1A1 mRNA expression was varied, namely additive, suppressive, or both. An additive effect was… CONTINUE READING

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