Potent inhibition of tumor necrosis factor-alpha production by tetrafluorothalidomide and tetrafluorophthalimides.

  title={Potent inhibition of tumor necrosis factor-alpha production by tetrafluorothalidomide and tetrafluorophthalimides.},
  author={Satomi Niwayama and Benjamin E. Turk and J. O. Liu},
  journal={Journal of medicinal chemistry},
  volume={39 16},

Study of the Interactions of Bovine Serum Albumin with the New Anti-Inflammatory Agent 4-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-N′-[(4-ethoxy-phenyl)methylidene]benzohydrazide Using a Multi-Spectroscopic Approach and Molecular Docking

The docking results and the results from the experimental studies are complimentary to each other and confirm that 6P binds at site II (sub-domain IIIA) of BSA.

A multi-step continuous flow synthesis of pomalidomide

A continuous 3–4 step flow approach for the synthesis of the pomalidomide and a few analogues is described, allowing a safe operation, an excellent reproducibility and an efficient process.

A Rational Insight into the Effect of Dimethyl Sulfoxide on TNF-α Activity

This study found that the sensitizing effect of actinomycin D on TNF-α-induced cell death depends upon the timing of these treatments and on the cell type, and will help to select an appropriate concentration of DMSO as a working solvent for the screening of water-insoluble T NF-α inhibitors.

QSAR, ADME and docking guided semi-synthesis and in vitro evaluation of 4-hydroxy-α-tetralone analogs for anti-inflammatory activity

The 4-hydroxy-α-tetralone virtual derivatives, which showed significant inhibition of TNF-α were subjected to docking and in-silico absorption, distribution, metabolism and excretion studies and the results showed similar binding affinity and bioavailability in compliance with the standard drug, Diclofenac.

Synthesis of phthalimides cross-conjugated with an azulene ring, and their structural, optical and electrochemical properties.

Results indicated that the substituents on the azulene ring greatly affect the optical and electrochemical properties of the molecules.

Thalidomide and Analogues

TNFα inhibitors as targets for protective therapies in MSA: a viewpoint

The relationship between αS and microglial activation depending on its aggregation state and its role in neuroinflammation is critically reviewed to explore the potential of TNFα inhibitors as a treatment strategy for MSA and other neurodegenerative diseases.

Therapeutic Effects of a Novel Phenylphthalimide Analog for Corneal Neovascularization and Retinal Vascular Leakage

DAID is a novel phenylphthalimide analog with potent effects on NV and retinal vascular leakage through downregulation of VEGF and inflammatory factors and has therapeutic potential.

Pomalidomide mitigates neuronal loss, neuroinflammation, and behavioral impairments induced by traumatic brain injury in rat

Pom dose-dependently ameliorated glutamate-mediated cytotoxic effects on cell viability and reduced microglial cell activation, significantly attenuating the induction of TNF-α and cytokine mRNA and protein induction.