Potent inhibition of the cytochrome P-450 3A-mediated human liver microsomal metabolism of a novel HIV protease inhibitor by ritonavir: A positive drug-drug interaction.

@article{Kumar1999PotentIO,
  title={Potent inhibition of the cytochrome P-450 3A-mediated human liver microsomal metabolism of a novel HIV protease inhibitor by ritonavir: A positive drug-drug interaction.},
  author={G. V. Narasimha Kumar and J J Dykstra and Ellen M Roberts and Venkata K. Jayanti and D. Hickman and John T Uchic and Yaochun Yao and Bruce W. Surber and Shince Thomas and G. Richard Granneman},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1999},
  volume={27 8},
  pages={902-8}
}
ABT-378 is a potent in vitro inhibitor of the HIV protease and is currently being developed for coadministration with another HIV protease inhibitor, ritonavir, as an oral therapeutic treatment for HIV infection. In the present study, the effect of ritonavir, a potent inhibitor of cytochrome P-450 (CYP) 3A, on the in vitro metabolism of ABT-378 was examined. Furthermore, the effect of ABT-378-ritonavir combinations on several CYP-dependent monooxygenase activities in human liver microsomes was… CONTINUE READING

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References

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Showing 1-10 of 44 references

Enhancement of ABT-378 pharmacokinetics when administered in combination with ritonavir

  • K Marsh, E McDonald, H Sham, D Kempf, D Norbeck
  • Proceedings of 4th Conference on Retroviruses and…
  • 1997
Highly Influential
4 Excerpts

Measurement of liver microsomal cytochrome P 450 ( CYP 2 D 6 ) activity using [ O - methyl - 14 C ] dextromethorphan

  • AD Rodrigues, MJ Kukulka, +6 authors JM Machinist
  • Anal Biochem
  • 1994
Highly Influential
1 Excerpt

Drug Metab Dispos25:1097–1100

  • DJ Kempf, A Molla, +22 authors D Norbeck
  • 1998

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