Potent inhibition of tau fibrillization with a multivalent ligand.

  title={Potent inhibition of tau fibrillization with a multivalent ligand.},
  author={Nicolette S. Honson and Jordan R. Jensen and Michael V Darby and Jeff Kuret},
  journal={Biochemical and biophysical research communications},
  volume={363 1},
Small-molecule inhibitors of tau fibrillization are under investigation as tools for interrogating the tau aggregation pathway and as potential therapeutic agents for Alzheimer's disease. Established inhibitors include thiacarbocyanine dyes, which can inhibit recombinant tau fibrillization in the presence of anionic surfactant aggregation inducers. In an effort to increase inhibitory potency, a cyclic bis-thiacarbocyanine molecule containing two thiacarbocyanine moieties was synthesized and… CONTINUE READING


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