Potent inhibition of human telomerase by nitrostyrene derivatives.

@article{Kim2003PotentIO,
  title={Potent inhibition of human telomerase by nitrostyrene derivatives.},
  author={Joo Hee Kim and Jun Hyun Kim and Gun Eui Lee and Jong Eun Lee and I. K. Chung},
  journal={Molecular pharmacology},
  year={2003},
  volume={63 5},
  pages={1117-24}
}
Telomerase activity is expressed in most types of cancer cells but not in normal somatic cells, suggesting that telomerase may be an important target for cancer chemotherapy. Inhibition of telomerase results in telomere erosion, leading to the subsequent growth arrest of cancer cells followed by senescence or cell death. In this study, we screened a chemical library for the inhibition of human telomerase, identifying three inhibitors. All compounds contained a common nitrostyrene moiety… CONTINUE READING

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