Potent inhibition of human phosphodiesterase-5 by icariin derivatives.

@article{DellAgli2008PotentIO,
  title={Potent inhibition of human phosphodiesterase-5 by icariin derivatives.},
  author={Mario Dell’Agli and Germana V. Galli and Esther Dal Cero and Federica Belluti and Riccardo Matera and Elisa Zironi and Giampiero Pagliuca and Enrica Bosisio},
  journal={Journal of natural products},
  year={2008},
  volume={71 9},
  pages={
          1513-7
        }
}
Plant extracts traditionally used for male impotence (Tribulus terrestris, Ferula hermonis, Epimedium brevicornum, Cinnamomum cassia), and the individual compounds cinnamaldehyde, ferutinin, and icariin, were screened against phosphodiesterase-5A1 (PDE5A1) activity. Human recombinant PDE5A1 was used as the enzyme source. Only E. brevicornum extract (80% inhibition at 50 microg/mL) and its active principle icariin (1) (IC50 5.9 microM) were active. To improve its inhibitory activity, 1 was… Expand
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