Potent inhibition of human influenza H5N1 virus by oligonucleotides derived by SELEX.

@article{Cheng2008PotentIO,
  title={Potent inhibition of human influenza H5N1 virus by oligonucleotides derived by SELEX.},
  author={Congsheng Cheng and Jie Dong and Lihong Yao and Aijun Chen and Runqing Jia and Lifang Huan and Jianqiang Guo and Yuelong Shu and Zhiqing Zhang},
  journal={Biochemical and biophysical research communications},
  year={2008},
  volume={366 3},
  pages={670-4}
}
New therapeutics are urgently needed for the treatment of pandemic influenza caused by H5N1 influenza virus mutants. Aptamer was a promising candidate for treatment and prophylaxis of influenza virus infections. In this study, systemic evolution of ligands through exponential enrichment (SELEX) was used to screen DNA aptamers targeted to recombinant HA1 proteins of the H5N1 influenza virus. After 11 rounds of selection, DNA aptamers that bind to the HA1 protein were isolated and shown to have… CONTINUE READING

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