Potent inhibition of human immunodeficiency virus type 1 in primary T cells and alveolar macrophages by a combination anti-Rev strategy delivered in an adeno-associated virus vector.

@article{Inouye1997PotentIO,
  title={Potent inhibition of human immunodeficiency virus type 1 in primary T cells and alveolar macrophages by a combination anti-Rev strategy delivered in an adeno-associated virus vector.},
  author={Roger T. Inouye and Baoxing Du and Deborah M Boldt-Houle and Antonio Ferrante and Iha Park and Scott M. Hammer and Lijie Duan and Jerome E. Groopman and Roger J. Pomerantz and Ernest F. Terwilliger},
  journal={Journal of virology},
  year={1997},
  volume={71 5},
  pages={4071-8}
}
The rate of viral replication appears to play a pivotal role in human immunodeficiency virus type 1 (HIV-1) pathogenesis and disease progression as it outstrips the capacity of the immune system to respond. Important cellular sites for HIV-1 production include T lymphocytes and tissue macrophages. Antiviral strategies, including newer treatment modalities such as gene therapy of HIV-1-susceptible cell populations, must be capable of engendering durable inhibitory effects to HIV-1 replication in… CONTINUE READING

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