Potent inhibition of human 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1 by the anti-carcinogenic and anti-inflammatory agent embelin.

@article{Schaible2013PotentIO,
  title={Potent inhibition of human 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1 by the anti-carcinogenic and anti-inflammatory agent embelin.},
  author={Anja Maria Schaible and Heidi Traber and Veronika Temml and Stefan M. Noha and Rosanna Filosa and Antonella Peduto and Christina Weinigel and Dagmar Barz and Daniela Schuster and Oliver Werz},
  journal={Biochemical pharmacology},
  year={2013},
  volume={86 4},
  pages={
          476-86
        }
}
Embelin (2,5-dihydroxy-3-undecyl-1,4-benzoquinone) possesses anti-inflammatory and anti-carcinogenic properties in vivo, and these features have been related to interference with multiple targets including XIAPs, NFκB, STAT-3, Akt and mTOR. However, interference with these proteins requires relatively high concentrations of embelin (IC₅₀>4 μM) and cannot fully explain its bioactivity observed in several functional studies. Here we reveal human 5-lipoxygenase (5-LO) and microsomal prostaglandin… CONTINUE READING
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