Potent inhibition of angiogenesis by wortmannin, a fungal metabolite.

  title={Potent inhibition of angiogenesis by wortmannin, a fungal metabolite.},
  author={Tsutomu Oikawa and Mitsuru Shimamura},
  journal={European journal of pharmacology},
  volume={318 1},
Wortmannin ([1S-(1 alpha, 6b alpha, 9a beta, 11 alpha, 11b beta)]-11-(acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1- (methoxymethyl)-9a, 11b-dimethyl-3 H-furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6,9-trione), a fungal metabolite that is as a selective inhibitor of phosphatidylinositol 3-kinase, was evaluated for its potential as an inhibitor of in vivo angiogenesis in a bioassay system involving growing chick embryo chorioallantoic membranes. It showed dose-dependent inhibitory activity against… CONTINUE READING


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