Potent inhibition of NFAT activation and T cell cytokine production by novel low molecular weight pyrazole compounds.

@article{Trevillyan2001PotentIO,
  title={Potent inhibition of NFAT activation and T cell cytokine production by novel low molecular weight pyrazole compounds.},
  author={James M Trevillyan and Xue Grace Chiou and Yue Wei Chen and Steve J Ballaron and Michael P Sheets and Martin L. Smith and Paul E Wiedeman and Usha Warrior and Julie Wilkins and Earl J. Gubbins and Gerard D. Gagn{\'e} and Jane A Fagerland and George W. Carter and Jay R Luly and Karl W. Mollison and Stevan W. Djuric},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 51},
  pages={48118-26}
}
NFAT (nuclear factor of activated T cell) proteins are expressed in most immune system cells and regulate the transcription of cytokine genes critical for the immune response. The activity of NFAT proteins is tightly regulated by the Ca(2+)/calmodulin-dependent protein phosphatase 2B/calcineurin (CaN). Dephosphorylation of NFAT by CaN is required for NFAT… CONTINUE READING