Potent inhibition of HIV-1 replication by backbone cyclic peptides bearing the Rev arginine rich motif.

@article{Chaloin2007PotentIO,
  title={Potent inhibition of HIV-1 replication by backbone cyclic peptides bearing the Rev arginine rich motif.},
  author={Laurent Chaloin and Fatima Smagulova and Elana Hariton-Gazal and Laurence Briant and Abraham Loyter and Christian A. Devaux},
  journal={Journal of biomedical science},
  year={2007},
  volume={14 5},
  pages={
          565-84
        }
}
Due to its essential role in the virus life cycle, the viral regulatory protein Rev constitutes an attractive target for the development of new antiviral molecules. In this work, a series of Backbone Cyclic Peptide (BCP) analogs that bear a conformationally constrained arginine rich motif (ARM) of Rev were tested for in vitro inhibition of HIV-1 replication. We observed a potent suppression of HIV-1 replication in chronically infected T lymphocytic cells treated with Rev-BCPs. We further… CONTINUE READING