Potent inhibition of DOT1L as treatment of MLL-fusion leukemia.

@article{Daigle2013PotentIO,
  title={Potent inhibition of DOT1L as treatment of MLL-fusion leukemia.},
  author={Scott R. Daigle and Edward J. Olhava and Carly A. Therkelsen and Aravind Basavapathruni and Lei Jin and Paula Ann Boriack-Sjodin and Christina J. Allain and Christine R. Klaus and Alejandra Raimondi and Margaret Porter Scott and Nigel J. Waters and Richard Chesworth and Mikel P. Moyer and Robert A Copeland and Victoria M. Richon and R. M. Pollock},
  journal={Blood},
  year={2013},
  volume={122 6},
  pages={
          1017-25
        }
}
Rearrangements of the MLL gene define a genetically distinct subset of acute leukemias with poor prognosis. Current treatment options are of limited effectiveness; thus, there is a pressing need for new therapies for this disease. Genetic and small molecule inhibitor studies have demonstrated that the histone methyltransferase DOT1L is required for the development and maintenance of MLL-rearranged leukemia in model systems. Here we describe the characterization of EPZ-5676, a potent and… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 251 CITATIONS, ESTIMATED 55% COVERAGE

Novel Drugs Targeting the Epigenome

VIEW 8 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

The histone methyltransferase DOT1L: regulatory functions and a cancer therapy target.

VIEW 8 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

ChIPSeqSpike : ChIP-seq data scaling with spike-in control

VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Targeting Histone Methylation in Cancer.

VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Clinically Applicable Inhibitors Impacting Genome Stability

VIEW 9 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2013
2020

CITATION STATISTICS

  • 22 Highly Influenced Citations

  • Averaged 42 Citations per year from 2017 through 2019

  • 6% Increase in citations per year in 2019 over 2018

References

Publications referenced by this paper.
SHOWING 1-10 OF 44 REFERENCES

The diverse functions of Dot1 and H3K79 methylation.

VIEW 11 EXCERPTS
HIGHLY INFLUENTIAL

H3K79 methylation profiles define murine and human MLL-AF4 leukemias.

VIEW 11 EXCERPTS
HIGHLY INFLUENTIAL

Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors.

VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL