Potent inhibition by star fruit of human cytochrome P450 3A (CYP3A) activity.

@article{Hidaka2004PotentIB,
  title={Potent inhibition by star fruit of human cytochrome P450 3A (CYP3A) activity.},
  author={M. Hidaka and Ken-Ichi Fujita and Tetsuya Ogikubo and K. Yamasaki and T. Iwakiri and M. Okumura and H. Kodama and K. Arimori},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2004},
  volume={32 6},
  pages={
          581-3
        }
}
There has been very limited information on the capacities of tropical fruits to inhibit human cytochrome P450 3A (CYP3A) activity. Thus, the inhibitory effects of tropical fruits on midazolam 1'-hydroxylase activity of CYP3A in human liver microsomes were evaluated. Eight tropical fruits such as common papaw, dragon fruit, kiwi fruit, mango, passion fruit, pomegranate, rambutan, and star fruit were tested. We also examined the inhibition of CYP3A activity by grapefruit (white) and Valencia… Expand
Inhibition of human liver cytochrome P450 by star fruit juice.
  • Jiang-Wei Zhang, Y. Liu, +9 authors L. Yang
  • Biology, Medicine
  • Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques
  • 2007
TLDR
Star fruit juice inhibited the seven CYP isoforms tested, with the strongest inhibitory effect against CYP2A6 and the least towards CYP3A4. Expand
Inhibitory Effects of Fruit Juices on Cytochrome P450 2C9 Activity in Vitro
TLDR
It is found that pineapple juice was a potent inhibitor of CYP2C9, and that the inhibitory effect might be due to the bromelain contained in pineapple. Expand
INHIBITORY EFFECTS OF FRUIT JUICES ON CYP3A ACTIVITY
TLDR
Commercial fruit juices also have the potential to inhibit CYP3A-catalzyed midazolam 1′-hydroxylation, suggesting that a mechanism-based inhibitory component was present in these fruit juices, as in the case of grapefruit. Expand
Mechanism-based inhibition of recombinant human cytochrome P450 3A4 by tomato juice extract.
TLDR
It is concluded that tomato juice contains one or more mechanism-based and competitive inhibitor(s) of CYP3A4, which was observed in other solanaceous plants, i.e., potato, eggplant, sweet pepper, and capsicum. Expand
Inhibitory Effect of Tea Beverages on Human Cytochrome P 450 3A (CYP 3A) Activity
In view of the lack of information on the extent to which tea beverages inhibit the activity of human cytochrome P 450 3A (CYP 3A), we investigated their effect on the midazolam 1'-hydroxylationExpand
TRANSIENT INHIBITION OF CYP3A IN RATS BY STAR FRUIT JUICE
TLDR
The results suggest that star fruit juice impairs the function of enteric CYP3A, but not of hepatic CYP2A, and that the effect of star fruit Juice is mainly reversible and transient. Expand
Pomegranate juice inhibits sulfoconjugation in Caco-2 human colon carcinoma cells.
TLDR
Results indicate that the inhibition of sulfotransferase activity by punicalagin in Caco-2 cells is responsible for the reductions seen in 1-naphthyl sulfate accumulation, and suggest that constituents of pomegranate juice impair the enteric functions of sulfoconjugation and that this might have effects upon the bioavailability of drugs and other compounds present in food and in the environment. Expand
Pomegranate juice effects on cytochrome P450S expression: in vivo studies.
TLDR
Pomegranate juice consumption decreased total hepatic CYP content as well as the expression of CYP1A2 and CYP3A, and Prevention of procarcinogen activation through CYP activity/expression inhibition may be involved in pomegranATE juice's effect on tumor initiation, promotion, and progression. Expand
EFFECTS OF POMEGRANATE JUICE ON HUMAN CYTOCHROME P450 3A (CYP3A) AND CARBAMAZEPINE PHARMACOKINETICS IN RATS
TLDR
It is discovered that a component(s) of pomegranate inhibits the human CYP3A-mediated metabolism of carbamazepine and alters the carbamazetine pharmacokinetics in rats. Expand
Effects of Pomegranate Juice on Human Cytochrome P450 2C9 and Tolbutamide Pharmacokinetics in Rats
TLDR
It is discovered that pomegranate juice inhibited human CYP2C9 activity and furthermore increased tolbutamide bioavailability in rats. Expand
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The capacities of citrus fruits to inhibit midazolam 1'-hydroxylase activity of cytochrome P450 3A (CYP3A) expressed in human liver microsomes were evaluated. Eight citrus fruits such as ama-natsu,Expand
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All six furanocoumarins showed stronger CYP3A inhibitory potencies after preincubation in the presence of NADPH, suggesting that both competitive and mechanism-based inhibition occur in a grapefruit juices-drug interaction. Expand
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Intersubject changes in felodipine and dehydrofelodipines AUC supported inhibition of both primary and secondary metabolic steps as a mechanism, and the interaction could not be predicted from baseline pharmacokinetics with water and did not result in more consistent bioavailability among individuals. Expand
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These furocoumarins are strong candidates for causative agents of grapefruit juice-mediated drug interaction, because of an inhibition potential that is equal to or stronger than the prototypical CYP3A4 inhibitor, ketoconazole, on liver microsomal testosterone 6 beta-hydroxylation. Expand
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The effect of echinacea (Echinacea purpurea root) on CYP activity in vivo was assessed by use of the CYP probe drugs caffeine, tolbutamide, dextromethorphan, and midazolam. Expand
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TLDR
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TLDR
Haemodialysis, especially on a daily basis, is the ideal treatment for star fruit intoxication and in severe cases, continuous methods of replacement therapy may provide a superior initial procedure, since rebound effects are a common event. Expand
Intoxication by star fruit (Averrhoa carambola) in six dialysis patients? (Preliminary report)
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  • Medicine
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  • 1998
TLDR
It appears that star fruit (Averrhoa carambola) contains an excitatory neurotoxin, and patients with renal failure on conservative or dialysis treatment should be dissuaded from ingestion of the fruit. Expand
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TLDR
Six men with borderline hypertension took felodipine 5 mg with water, grapefruit juice, or orange juice; the bioavailability with grapefruit Juice was lower, diastolic blood pressure lower, and heart rate higher with Grapefruit juice than with water. Expand
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