Potent inhibition by star fruit of human cytochrome P450 3A (CYP3A) activity.

  title={Potent inhibition by star fruit of human cytochrome P450 3A (CYP3A) activity.},
  author={Muneaki Hidaka and Ken-Ichi Fujita and Tetsuya Ogikubo and Keishi Yamasaki and Tomomi Iwakiri and Manabu Okumura and Hirofumi Kodama and Kazuhiko Arimori},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  volume={32 6},
There has been very limited information on the capacities of tropical fruits to inhibit human cytochrome P450 3A (CYP3A) activity. Thus, the inhibitory effects of tropical fruits on midazolam 1'-hydroxylase activity of CYP3A in human liver microsomes were evaluated. Eight tropical fruits such as common papaw, dragon fruit, kiwi fruit, mango, passion fruit, pomegranate, rambutan, and star fruit were tested. We also examined the inhibition of CYP3A activity by grapefruit (white) and Valencia… 

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