Potent induction of tumor immunity by combining tumor cryoablation with anti-CTLA-4 therapy.

@article{Waitz2012PotentIO,
  title={Potent induction of tumor immunity by combining tumor cryoablation with anti-CTLA-4 therapy.},
  author={Rebecca Waitz and Stephen B. Solomon and Elena Nadia Petre and Anne E. Trumble and Marcella Fass{\`o} and Larry Norton and James P Allison},
  journal={Cancer research},
  year={2012},
  volume={72 2},
  pages={430-9}
}
Thermal ablation to destroy tumor tissue may help activate tumor-specific T cells by elevating the presentation of tumor antigens to the immune system. However, the antitumor activity of these T cells may be restrained by their expression of the inhibitory T-cell coreceptor CTLA-4, the target of the recently U.S. Food and Drug Administration-approved antibody drug ipilumimab. By relieving this restraint, CTLA-4-blocking antibodies such as ipilumimab can promote tumor rejection, but the full… CONTINUE READING
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