Potent induction of the adaptive response by a weak mutagen, methyl iodide, in Escherichia coli.

@article{Takahashi1987PotentIO,
  title={Potent induction of the adaptive response by a weak mutagen, methyl iodide, in Escherichia coli.},
  author={Kazuhiko Takahashi and Yoshiyuki Kawazoe},
  journal={Mutation research},
  year={1987},
  volume={180 2},
  pages={
          163-9
        }
}
Methyl iodide (MeI), a weakly mutagenic and highly chemoselective chemical, was tested for its abilities to induce the adaptive and SOS responses in E. coli CSH26/pMCP1000 (alkA'-lacZ') and CSH26/pSK1002 (umuC'-lacZ'). MeI induced the adaptive response effectively but gave a very weak SOS response. Its potent ability in inducing the adaptive response was also demonstrated by adaptation to both the mutagenic and killing effects of N-methyl-N-nitrosourea (MNU) in E. coli WP2 cells. Simultaneous… CONTINUE READING