Potent in vitro synergism of fluconazole and berberine chloride against clinical isolates of Candida albicans resistant to fluconazole.

@article{Quan2006PotentIV,
  title={Potent in vitro synergism of fluconazole and berberine chloride against clinical isolates of Candida albicans resistant to fluconazole.},
  author={Hua Quan and Ying-ying Cao and Zheng M Xu and Jing-Xia Zhao and Ping-hui Gao and Xiao-feng Qin and Yuanying Jiang},
  journal={Antimicrobial agents and chemotherapy},
  year={2006},
  volume={50 3},
  pages={1096-9}
}
In vitro interaction of fluconazole and berberine chloride was investigated against 40 fluconazole-resistant clinical isolates of Candida albicans. Synergism in fungistatic activity was found with the checkerboard microdilution assay. The findings of agar diffusion tests and time-kill curves confirmed the synergistic interaction, but no antagonistic action was observed.