Potent hypocholesterolemic activity of novel ureido phenoxyisobutyrates correlates with their intrinsic fibrate potency and not with their ACAT inhibitory activity.

@article{Hawke1997PotentHA,
  title={Potent hypocholesterolemic activity of novel ureido phenoxyisobutyrates correlates with their intrinsic fibrate potency and not with their ACAT inhibitory activity.},
  author={R L Hawke and James M. Jr. Chapman and Deborah A. Winegar and Jo A Salisbury and R M Welch and A I Brown and K W Franzmann and Christophe Sigel},
  journal={Journal of lipid research},
  year={1997},
  volume={38 6},
  pages={
          1189-203
        }
}
The hypocholesterolemic activity for novel ureido fibrate analogues was found to be over 100-fold greater than for any "second-generation" fibrate in cholesterol-fed rats. A comparison of 12 related analogues revealed that the optimal configuration for a urea-bridging region located between two aromatic rings consisted of a trisubstituted nitrogen, optimally substituted with a C7 alkyl chain and linked by dimethylene to a phenoxyisobutyrate moiety found in most fibrate analogues. The… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 52 references

1995.15Deoxy-delta 12,14 prostaglandin 52 is a ligand for the adipocyte

R. M. Evans
1995

Hypolipidemic activity of select fibrates correlates to changes in hepatic apolipoprotein GI11 expression: a po

S. Haubenwallner, A. D. Essenburg, +8 authors C. L. Bisgaier
1995

PPAR: a key nuclear factor in nutrient/gene interactions

B. Desvergne, W. Wahli
Znducibb Gene Expression • 1995