Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein.

Abstract

The multifactorial nature of chemotherapy failure in controlling cancer is often associated with the occurrence of multidrug resistance (MDR), a phenomenon likely related to the increased expression of members of the ATP binding cassette (ABC) transporter superfamily. In this respect, the most extensively characterized MDR transporters include ABCB1 (also… (More)
DOI: 10.1021/jm201305y

Topics

6 Figures and Tables