Potent effects of the total saponins from Dioscorea nipponica Makino against streptozotocin-induced type 2 diabetes mellitus in rats.

@article{Yu2015PotentEO,
  title={Potent effects of the total saponins from Dioscorea nipponica Makino against streptozotocin-induced type 2 diabetes mellitus in rats.},
  author={Hao Yu and Lingli Zheng and Lina Xu and Lianhong Yin and Yuan Lin and Hua Li and Kexin Liu and Jinyong Peng},
  journal={Phytotherapy research : PTR},
  year={2015},
  volume={29 2},
  pages={228-40}
}
The aim of the present paper was to investigate the effects and possible mechanisms of the total saponins from Dioscorea nipponica Makino (TSDN) against type 2 diabetes mellitus. Streptozotocin (STZ) with high-fat diet induced type 2 diabetes mellitus (T2DM) rats were treated with TSDN. Some biochemical parameters, target proteins and genes were investigated. The results showed that TSDN decreased the levels of food/water intake, fasting blood glucose and serum lipid parameters, ameliorated… CONTINUE READING