Potent effects of AP3A and AP4A on coronary resistance and autacoid release of intact rabbit hearts.


We investigated effects of platelet-derived dinucleotides diadenosine 5',5"'-P1,P3-triphosphate (AP3A) and diadenosine 5',5"'-P1,P4-tetraphosphate (AP4A) on coronary vasculature. In isolated rabbit hearts, saline perfused at constant flow (36 +/- 3 ml/min), AP3A and AP4A induced dose-dependent decreases in coronary perfusion pressure. Dose-effect curves of… (More)


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