Potent cytotoxic lignans from Justicia procumbens and their effects on nitric oxide and tumor necrosis factor-alpha production in mouse macrophages.

@article{Day2002PotentCL,
  title={Potent cytotoxic lignans from Justicia procumbens and their effects on nitric oxide and tumor necrosis factor-alpha production in mouse macrophages.},
  author={S H Day and Yi-Chen Lin and Mei-Lin Tsai and L Y Tsao and H H Ko and M I Chung and Jeng-Chang Lee and Jih Pyang Wang and S. -J. Won and Chun-Nan Lin},
  journal={Journal of natural products},
  year={2002},
  volume={65 3},
  pages={379-81}
}
A new lignan glycoside, 4-O-alpha-L-arabinopyranosyl-(1' "-->2' ')-beta-D-apiofuranosyldiphyllin (2), named procumbenoside A, and 11 known compounds were isolated from the whole plant of Justicia procumbens. The structure of 2 was established by spectral analysis and chemical methods. The known compounds justicidin A (1), diphyllin (3), and tuberculatin (4) showed potent cytotoxic effects against a number of cancer cells in vitro. Compounds 1 and 4 also strongly enhanced tumor-necrosis factor… CONTINUE READING