Potent competitive interactions of some brominated flame retardants and related compounds with human transthyretin in vitro.

@article{Meerts2000PotentCI,
  title={Potent competitive interactions of some brominated flame retardants and related compounds with human transthyretin in vitro.},
  author={Ilonka A T M Meerts and Jelmer J van Zanden and E A Luijks and I van Leeuwen-Bol and G{\"o}ran Marsh and Eva Jakobsson and {\AA}ke Lennart Bergman and Abraham A. Brouwer},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2000},
  volume={56 1},
  pages={95-104}
}
Brominated flame retardants such as polybrominated diphenyl ethers (PBDEs), pentabromophenol (PBP), and tetrabromobisphenol A (TBBPA) are produced in large quantities for use in electronic equipment, plastics, and building materials. Because these compounds have some structural resemblance to the thyroid hormone thyroxine (T(4)), it was suggested that they may interfere with thyroid hormone metabolism and transport, e.g., by competition with T(4) on transthyretin (TTR). In the present study, we… CONTINUE READING
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