Potent blood coagulant activity of human semen due to prostasome-bound tissue factor.

@article{Fernndez1997PotentBC,
  title={Potent blood coagulant activity of human semen due to prostasome-bound tissue factor.},
  author={Jos{\'e} Aneiros Fern{\'a}ndez and Mary Jo Heeb and K. P. Radtke and John H. Griffin},
  journal={Biology of reproduction},
  year={1997},
  volume={56 3},
  pages={757-63}
}
Human semen contains very potent blood clotting activity; for example, seminal serum diluted up to 10,000-fold significantly decreased the recalcification clotting time of blood plasma. This seminal coagulant activity was dependent on factor X and calcium ions, suggesting the presence of a facto X activator. Immunoblotting analysis and immunoadsorption studies confirmed the presence of tissue factor antigen (45 kDa) in semen. Centrifugation studies suggested that tissue factor was membrane… CONTINUE READING

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