Potent block of inactivation-deficient Na+ channels by n-3 polyunsaturated fatty acids.

@article{Xiao2006PotentBO,
  title={Potent block of inactivation-deficient Na+ channels by n-3 polyunsaturated fatty acids.},
  author={Yong-Fu Xiao and Li Ma and Sho-Ya Wang and Mark E. Josephson and Ging Kuo Wang and James P. Morgan and Alexander Leaf},
  journal={American journal of physiology. Cell physiology},
  year={2006},
  volume={290 2},
  pages={
          C362-70
        }
}
A voltage-gated, small, persistent Na(+) current (I(Na)) has been shown in mammalian cardiomyocytes. Hypoxia potentiates the persistent I(Na) that may cause arrhythmias. In the present study, we investigated the effects of n-3 polyunsaturated fatty acids (PUFAs) on I(Na) in HEK-293t cells transfected with an inactivation-deficient mutant (L409C/A410W) of the alpha-subunit (hH1(alpha)) of human cardiac Na(+) channels (hNav1.5) plus beta(1)-subunits. Extracellular application of 5 microM… 
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