Potent antitumor efficacy of interleukin-18 delivered by conditionally replicative adenovirus vector in renal cell carcinoma-bearing nude mice via inhibition of angiogenesis.

@article{Zheng2009PotentAE,
  title={Potent antitumor efficacy of interleukin-18 delivered by conditionally replicative adenovirus vector in renal cell carcinoma-bearing nude mice via inhibition of angiogenesis.},
  author={Junnian Zheng and Dongsheng Pei and Fang-Hao Sun and Xin-Yuan Liu and Li-jun Mao and Bao-fu Zhang and R Wen and Wei Xu and Z. Y. Shi and Jun-jie Liu and Wang Li},
  journal={Cancer biology & therapy},
  year={2009},
  volume={8 7},
  pages={599-606}
}
It has been demonstrated that interleukin 18 (IL-18) exerts antitumor activity. In this study, we investigated whether oncolytic adenovirus-mediated gene transfer of IL-18 could induce strong antitumor activity. A tumor-selective replicating adenovirus expressing IL-18 (ZD55-IL-18) was constructed by insertion of an IL-18 expression cassette into the ZD55 vector, which is based on deletion of the adenoviral E1B 55-kDa gene. ZD55-IL-18 could express substantially more IL-18 than Ad-IL-18 because… CONTINUE READING

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