Potent antitumor activity and improved pharmacological profile of ST1481, a novel 7-substituted camptothecin.

@article{Cesare2001PotentAA,
  title={Potent antitumor activity and improved pharmacological profile of ST1481, a novel 7-substituted camptothecin.},
  author={M De Cesare and G Pratesi and P Perego and Nives Carenini and S Tinelli and L Merlini and S Penco and C Pisano and F Bucci and Loredana Vesci and S Pace and F Capocasa and Paolo Carminati and Franco Zunino},
  journal={Cancer research},
  year={2001},
  volume={61 19},
  pages={7189-95}
}
  • M De Cesare, G Pratesi, +11 authors Franco Zunino
  • Published 2001 in Cancer research
Relevant drawbacks of the molecular structure and mechanism of the action of camptothecins are the instability of the E ring lactone and the reversibility of drug-target interaction. Such features are expected to limit the clinical efficacy of conventional camptothecins. In an attempt to overcome these limitations and to improve the pharmacological profile of camptothecins, a novel series of seven modified lipophilic analogues was synthesized based on the hypothesis that lipophilicity could… CONTINUE READING
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