Potent antinociceptive effects of clonidine systemically administered in an experimental model of clinical pain, the arthritic rat.

@article{Kayser1992PotentAE,
  title={Potent antinociceptive effects of clonidine systemically administered in an experimental model of clinical pain, the arthritic rat.},
  author={Val{\'e}rie Kayser and Gis{\`e}le Guilbaud and Jean Marie Besson},
  journal={Brain research},
  year={1992},
  volume={593 1},
  pages={7-13}
}
The effects of various doses of the alpha-2 adrenoceptor agonist clonidine administered systemically (30, 50 and 100 micrograms/kg i.v.), were investigated on the vocalization threshold to paw pressure in normal rats and in rats with Freund's adjuvant-induced arthritis. Previous results have suggested that there is an increase in the activity of the bulbospinal noradrenergic systems in these arthritic animals. In the present study, clonidine led to significant antinociceptive effects in both… CONTINUE READING