Potent antinociceptive effects of Kelatorphan (a highly efficient inhibitor of multiple enkephalin-degrading enzymes) systemically administered in normal and arthritic rats

@article{Kayser1989PotentAE,
  title={Potent antinociceptive effects of Kelatorphan (a highly efficient inhibitor of multiple enkephalin-degrading enzymes) systemically administered in normal and arthritic rats},
  author={Val{\'e}rie Kayser and M. -C. Fourni{\'e}-Zaluski and Gis{\'e}le Guilbaud and B. Roques},
  journal={Brain Research},
  year={1989},
  volume={497},
  pages={94-101}
}
Antinociceptive effects of RB101, a complete inhibitor of enkephalin-catabolizing enzymes, are enhanced by a cholecystokinin type B receptor antagonist, as revealed by noxiously evoked spinal c-Fos expression in rats.
TLDR
Results show that RB101 dose-dependently decreases carrageenin-evoked spinal c-Fos expression, and the effectiveness of RB101 can be revealed by preadministration of the CCK(B) receptor antagonist CI988.
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References

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Effects of kelatorphan and other peptidase inhibitors on the in vitro and in vivo release of methionine-enkephalin-like material from the rat spinal cord.
TLDR
Compared to thiorphan plus bestatin, kelatorphan exerts additional inhibitory effects on dipeptidylaminopeptidase activity and the present results could indicate that this enzyme also may be involved in the inactivation of extracellular Met-enkephalin at the spinal level in rats.
Functional Response of Multiple Opioid Systems to Chronic Arthritic Pain in the Rat a
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TLDR
In their effects in this test, the narcotic antagonists resemble nonnarcotic analgesics.
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