Potent antimicrobial activity of 3-(4,5-diaryl-1H-imidazol-2-yl)-1H-indole derivatives against methicillin-resistant Staphylococcus aureus.

@article{AlQawasmeh2010PotentAA,
  title={Potent antimicrobial activity of 3-(4,5-diaryl-1H-imidazol-2-yl)-1H-indole derivatives against methicillin-resistant Staphylococcus aureus.},
  author={Raed A. Al-Qawasmeh and M. Huesca and Venkata Nedunuri and R. Peralta and Jim A. Wright and Y. Lee and A. Young},
  journal={Bioorganic \& medicinal chemistry letters},
  year={2010},
  volume={20 12},
  pages={
          3518-20
        }
}
A new series of antimicrobial derivatives [3-(4,5-diaryl-1H-imidazol-2-yl)-1H-indole)] have been synthesized with potent activity against strains of Staphylococcus aureus, including methicillin-resistant strains (MRSA). Compound 17 [3-(4,5-bis(4-fluorophenyl)-1H-imidazol-2-yl)-5-bromo-1H-indole], the most active derivative was shown to inhibit the growth of all Gram-positive strains tested, including vancomycin resistant Enterococcus faecalis and Enterococcus faecium with no activity against… Expand
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