• DOI:10.1128/AAC.39.12.2606
Corpus ID: 5181019

Potent antimalarial activity of the alkaloid nitidine, isolated from a Kenyan herbal remedy.

@article{Gakunju1995PotentAA,
  title={Potent antimalarial activity of the alkaloid nitidine, isolated from a Kenyan herbal remedy.},
  author={D. M. Gakunju and E. Mberu and S. F. Dossaji and A. I. Gray and R. Waigh and P. Waterman and W. Watkins},
  journal={Antimicrobial agents and chemotherapy},
  year={1995},
  volume={39},
  pages={2606 - 2609}
}

D. M. Gakunju, E. Mberu, +4 authors W. Watkins

Published 1995

Biology, Medicine

Antimicrobial agents and chemotherapy

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Bioassay-guided fractionation of extracts of Toddalia asiatica, a plant used by the Pokot tribe of Kenya to treat fevers, has yielded the alkaloid nitidine as the major antimalarial component. Fractions containing nitidine have in vitro 50% inhibitory concentrations against Plasmodium falciparum in the range of 9 to 108 ng/ml for a range of chloroquine-susceptible and -resistant strains. The results show a lack of cross-resistance between chloroquine and nitidine.