Potent antigen-specific immune response induced by infusion of spleen cells coupled with succinimidyl-4-(N-maleimidomethyl cyclohexane)-1-carboxylate (SMCC) conjugated antigens.

Abstract

In the present study, we report our recently developed new approach to inducing antigen-specific immune response. We use two nucleophilic substitution "click" chemistry processes to successfully couple protein antigens or peptides to mouse spleen cells or T cells by a heterobifunctional crosslinker, succinimidyl-4-(N-maleimidomethyl cyclohexane)-1… (More)
DOI: 10.1016/j.intimp.2015.12.023

Topics

Cite this paper

@article{Guo2016PotentAI, title={Potent antigen-specific immune response induced by infusion of spleen cells coupled with succinimidyl-4-(N-maleimidomethyl cyclohexane)-1-carboxylate (SMCC) conjugated antigens.}, author={Yixian Guo and Tyler Werbel and Sui-gui Wan and Haitao Wu and Yaohua Li and Michael J. Clare-Salzler and Chang-qing Xia}, journal={International immunopharmacology}, year={2016}, volume={31}, pages={158-68} }