Potent anti-seizure effects of D-leucine

  title={Potent anti-seizure effects of D-leucine},
  author={Adam L. Hartman and Polan T Santos and Kenneth J. O'Riordan and Carl E Stafstrom and J. Marie Hardwick},
  journal={Neurobiology of Disease},
There are no effective treatments for millions of patients with intractable epilepsy. High-fat ketogenic diets may provide significant clinical benefit but are challenging to implement. Low carbohydrate levels appear to be essential for the ketogenic diet to work, but the active ingredients in dietary interventions remain elusive, and a role for ketogenesis has been challenged. A potential antiseizure role of dietary protein or of individual amino acids in the ketogenic diet is understudied. We… CONTINUE READING


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