Potent anti-inflammatory and antinociceptive activity of the endothelin receptor antagonist bosentan in monoarthritic mice

@inproceedings{Imhof2011PotentAA,
  title={Potent anti-inflammatory and antinociceptive activity of the endothelin receptor antagonist bosentan in monoarthritic mice},
  author={A. Imhof and Laura Gl{\"u}ck and Mieczyslaw R. Gajda and Rolf Br{\"a}uer and H. G. Schaible and Stefan Schulz},
  booktitle={Arthritis research & therapy},
  year={2011}
}
INTRODUCTION Endothelins are involved in tissue inflammation, pain, edema and cell migration. Our genome-wide microarray analysis revealed that endothelin-1 (ET-1) and endothelin-2 (ET-2) showed a marked up-regulation in dorsal root ganglia during the acute phase of arthritis. We therefore examined the effects of endothelin receptor antagonists on the development of arthritis and inflammatory pain in monoarthritic mice. METHODS Gene expression was examined in lumbar dorsal root ganglia two… CONTINUE READING

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