Potent anti-Trypanosoma cruzi activities of oxidosqualene cyclase inhibitors.

  title={Potent anti-Trypanosoma cruzi activities of oxidosqualene cyclase inhibitors.},
  author={Frederick S Buckner and John H. Griffin and Aaron J Wilson and Wesley C E Van Voorhis},
  journal={Antimicrobial agents and chemotherapy},
  volume={45 4},
Trypanosoma cruzi is the protozoan agent that causes Chagas' disease, a major health problem in Latin America. Better drugs are needed to treat infected individuals. The sterol biosynthesis pathway is a potentially excellent target for drug therapy against T. cruzi. In this study, we investigated the antitrypanosomal activities of a series of compounds designed to inhibit a key enzyme in sterol biosynthesis, oxidosqualene cyclase. This enzyme converts 2,3-oxidosqualene to the tetracyclic… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 19 extracted citations


Publications referenced by this paper.
Showing 1-10 of 33 references

Squalene epoxidase and oxidosqualene : lanosterol cyclase — key enzymes in cholesterol biosynthesis

  • G. D. Prestwich
  • 1999

Squalene epoxidase and oxidosqualene: lanosterol cyclase—key enzymes in cholesterol biosynthesis, p. 267–298

  • I. Abe, G. D. Prestwich
  • 1999

Similar Papers

Loading similar papers…