Potent anti-Trypanosoma cruzi activities of oxidosqualene cyclase inhibitors.

@article{Buckner2001PotentAC,
  title={Potent anti-Trypanosoma cruzi activities of oxidosqualene cyclase inhibitors.},
  author={Frederick S Buckner and John H. Griffin and Aaron J Wilson and Wesley C E Van Voorhis},
  journal={Antimicrobial agents and chemotherapy},
  year={2001},
  volume={45 4},
  pages={1210-5}
}
Trypanosoma cruzi is the protozoan agent that causes Chagas' disease, a major health problem in Latin America. Better drugs are needed to treat infected individuals. The sterol biosynthesis pathway is a potentially excellent target for drug therapy against T. cruzi. In this study, we investigated the antitrypanosomal activities of a series of compounds designed to inhibit a key enzyme in sterol biosynthesis, oxidosqualene cyclase. This enzyme converts 2,3-oxidosqualene to the tetracyclic… CONTINUE READING

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