Potent and specific inhibition of p60v-src protein kinase both in vivo and in vitro by radicicol.

@article{Kwon1992PotentAS,
  title={Potent and specific inhibition of p60v-src protein kinase both in vivo and in vitro by radicicol.},
  author={Ho Jeong Kwon and Minoru Yoshida and Yasuhisa Fukui and Sueharu Horinouchi and Teruhiko Beppu},
  journal={Cancer research},
  year={1992},
  volume={52 24},
  pages={6926-30}
}
A fungal metabolite, radicicol, with a macrocyclic ring induced the reversal of transformed phenotypes of v-src-transformed fibroblasts (Rous sarcoma virus-transformed 3Y1 rat fibroblast) at a quite low concentration of 0.1 microgram/ml. Actin stress fibers reappeared in the transformed cells after treatment with radicicol. Radicicol reduced the intracellular level of autophosphorylation of p60v-src as well as the level of other tyrosine-phosphorylated proteins in a dose-dependent manner. In… CONTINUE READING