Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

@article{Fire1998PotentAS,
  title={Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans},
  author={A. Fire and S. Xu and M. Montgomery and S. Kostas and Samuel E. Driver and C. Mello},
  journal={Nature},
  year={1998},
  volume={391},
  pages={806-811}
}
Experimental introduction of RNA into cells can be used in certain biological systems to interfere with the function of an endogenous gene. [...] Key Result After injection into adult animals, purified single strands had at most a modest effect, whereas double-stranded mixtures caused potent and specific interference. The effects of this interference were evident in both the injected animals and their progeny.Expand
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