Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

@article{Fire1998PotentAS,
  title={Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans},
  author={Andrew Fire and Siqun Xu and Mary K. Montgomery and Steven A. Kostas and Samuel E. Driver and Craig C. Mello},
  journal={Nature},
  year={1998},
  volume={391},
  pages={806-811}
}
Experimental introduction of RNA into cells can be used in certain biological systems to interfere with the function of an endogenous gene1,2. Such effects have been proposed to result from a simple antisense mechanism that depends on hybridization between the injected RNA and endogenous messenger RNA transcripts. RNA interference has been used in the nematode Caenorhabditis elegans to manipulate gene expression3,4. Here we investigate the requirements for structure and delivery of the… CONTINUE READING
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